About Iovance Biotherapeutics, Inc.  Iovance Biotherapeutics, Inc.  is the global leader in innovating, developing, and delivering tumor infiltrating lymphocyte (TIL) cell therapies for patients with solid tumors. Amtagvi® (lifileucel) is the first FDA-approved, one-time treatment for previously treated advanced melanoma, now approved in three global markets and available at more than 95 authorized treatment centers. The Iovance TIL platform spans registrational trials and next-generation programs in additional solid tumors, including gene-edited and IL-12 tethered TIL therapies, next-generation IL-2, and precision immuno-oncology approaches. As the first and only company to take TIL therapy from concept to a broadly accessible commercial treatment, Iovance operates as an end-to-end cell therapy company, anchored by fully owned, centralized U.S.-based manufacturing that is scaled to serve thousands of cancer patients worldwide each year. For more information, please visit www.iovance.com. Amtagvi® and its accompanying design marks, Proleukin®, Iovance®, and IovanceCares™ are trademarks and registered trademarks of Iovance Biotherapeutics, Inc. or its subsidiaries. All other trademarks and registered trademarks are the property of their respective owners. Information on Iovance’s broad, industry-leading patent portfolio is available on the Intellectual Property page on www.iovance.com. Overview In the U.S. Cell and Gene therapy (CGT) market, access decisions span Commercial and Government Health Plans as well as clinical, formulary, finance, and value-analysis stakeholders within Authorized Treatment Centers (ATCs), integrated delivery networks (IDNs), and other provider organizations. Iovance is seeking a Senior Manager, U.S. Market Access Marketing, to translate clinical and economic evidence into differentiated value messaging and resources for AMTAGVI and pipeline therapies. This individual will help shape and lead tactical execution of the U.S. market access strategy across payer and provider channels, focusing on ATC financial feasibility, pre-approval information exchange (PIE), total cost of care, site of care, budget impact, and cost-effectiveness. Essential Functions and Responsibilities - Support development and lead execution of U.S. market access strategy and annual tactical plans for AMTAGVI and pipeline therapies - Support development of differentiated payer and provider value propositions that translate clinical, economic, and humanistic (PROs/HRQoL) evidence into clear, customer-relevant value messages - Lead development and lifecycle management of payer and ATC resources, including value presentations, AMCP dossiers, P&T materials, PIE materials, FDAMA Section 114 resources, economic tools, and reimbursement education tools - Partner with HEOR/RWE, Brand Marketing, Medical Affairs, BAI and other cross-functional partners to identify evidence gaps and shape analyses addressing cost of care, site of care, budget impact, cost-effectiveness, and patient outcomes - Generate actionable payer and provider insights through market research, advisory boards, field feedback, competitive intelligence, coverage monitoring, and analytics - Train and equip field teams with approved messaging, resources, and pull-through tools and incorporate field feedback to improve execution - Manage agencies, vendors, budgets, timelines, and promotional review to ensure compliant, high-quality execution and effective investment - Translate evolving payer, provider, reimbursement, policy, and competitive dynamics into recommendations for pricing, contracting, channel, evidence, and field execution - Maintain the highest standards of compliance, professional conduct, and ethical decision-making Travel - Travel required, including overnights and some weekends (up to 20%) Required Education, Skills, and Knowledge - Bachelor’s degree in life sciences, pharmacy, business, health economics, public health, economics, or a related field - 7+ years with a bachelor’s degree, or 5+ years with an advanced degree, in pharmaceutical, biotechnology, healthcare, or managed markets, including 3+ years in U.S. market access marketing or strategy - Experience developing payer- or provider-facing value propositions and materials and navigating medical, legal, and regulatory review - Strong knowledge of the U.S. payer and provider landscape, medical-benefit reimbursement, utilization management, and health-system financial decision-making - Ability to translate complex clinical and economic evidence into clear strategy and customer communications - Proven cross-functional leadership, agency and project management, and ability to influence without direct authority - Excellent written, verbal, presentation, analytical, and Microsoft Office skills Preferred Education, Skills, and Knowledge - Doctorate degree (PharmD, MD, DO or PhD) preferred - Cell therapy or hematology/oncology experience preferred The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodation may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request accommodation. Physical Demands and Activities Required - Must be able to remain in a stationary position standing or sitting for prolonged periods of time - Must be able to move about inside an office and exert up to 10 pounds of force occasionally or a negligible amount of force frequently or constantly to lift, carry, push, pull, or otherwise move objects - Must have visual acuity to perform activities such as preparing and analyzing data and figures, viewing a computer screen, and extensive reading - This position requires repetitive motion, substantial movements (motions) of the wrist, hands, and/or fingers - Must be able to communicate with others to exchange information Mental: Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines Work Environment This job operates in a professional or remote office environment and requires operating standard office equipment and keyboards. #li-remote The annual base salary we reasonably expect to pay is listed. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of the role, job duties/requirements, and relevant education, experience and skills. Pay Transparency $140,000—$160,000 USD The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time. Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer, our employees and applicants will be considered without regard to an individual’s race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities, please contact careers@iovance.com. By voluntarily providing information and clicking “Submit Application”, you explicitly consent to the collection and use of your personal information for the purposes described above and in our Candidate Privacy Notice.

Senior Manager, Market Access Marketing

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