About Iovance Biotherapeutics, Inc.  Iovance Biotherapeutics, Inc.  is the global leader in innovating, developing, and delivering tumor infiltrating lymphocyte (TIL) cell therapies for patients with solid tumors. Amtagvi® (lifileucel) is the first FDA-approved, one-time treatment for previously treated advanced melanoma, now approved in three global markets and available at more than 95 authorized treatment centers. The Iovance TIL platform spans registrational trials and next-generation programs in additional solid tumors, including gene-edited and IL-12 tethered TIL therapies, next-generation IL-2, and precision immuno-oncology approaches. As the first and only company to take TIL therapy from concept to a broadly accessible commercial treatment, Iovance operates as an end-to-end cell therapy company, anchored by fully owned, centralized U.S.-based manufacturing that is scaled to serve thousands of cancer patients worldwide each year. For more information, please visit www.iovance.com. Amtagvi® and its accompanying design marks, Proleukin®, Iovance®, and IovanceCares™ are trademarks and registered trademarks of Iovance Biotherapeutics, Inc. or its subsidiaries. All other trademarks and registered trademarks are the property of their respective owners. Information on Iovance’s broad, industry-leading patent portfolio is available on the Intellectual Property page on www.iovance.com. Overview The Executive Director, Global Commercial Proleukin leads the global Proleukin business and sets its long-range strategy and operating priorities for the United States and international markets, including licensed and unlicensed countries. The role is accountable for business performance and coordinates commercial plans with Clinical, Regulatory, Manufacturing, Medical Affairs, Market Access, Sales, Legal, Finance, Supply Chain, and regional teams to support growth, customer needs, reliable supply, and compliance. The Executive Director advises senior leaders on business results, major risks, spending priorities, and growth opportunities and represents Proleukin in leadership reviews and decision-making forums. The role requires sound judgment in a highly regulated environment, strong scientific knowledge, and a clear understanding of the market for oncology therapies, including hospital-administered products. The Executive Director also determines staffing needs, develops leaders, supports succession planning, and sets clear expectations for team performance and collaboration. Essential Functions and Responsibilities - Set and communicate the global commercial strategy, priorities, and performance measures for Proleukin - Own profit-and-loss performance and advise senior leaders on business results, spending priorities, risks, and growth opportunities - Make decisions on inventory, distribution, market priorities, budgets, staffing, and business risks - Own annual and quarterly revenue forecasts, expense budgets, planning assumptions, and spending recommendations - Oversee distribution and inventory to meet demand, manage cost, and maintain supply - Set performance measures and use customer data and business analysis to guide decisions and address performance issues - Lead global business and customer planning, including account coverage, customer groups, distribution, forecasting, and short- and long-range plans - Coordinate commercial strategy with Clinical, Regulatory, Medical Affairs, Market Access, Sales, Legal, Finance, Manufacturing, Supply Chain, and regional teams and represent the business in leadership reviews and strategic planning meetings - Partner with the Vice President of Sales to align commercial strategy, field priorities, training, and performance expectations - Partner with U.S. and Global Market Access leaders to plan for reimbursement changes and address barriers to patient access - Set direction and approve marketing plans and materials, ensuring they support the brand strategy and meet compliance requirements - Lead annual and long-range commercial planning, including key choices, budget recommendations, planning assumptions, and business reviews - Assess and recommend product lifecycle, access, distribution, partnership, and business development opportunities - Guide engagement with clinicians, providers, payers, patient advocates, and other external groups - Guide advocacy, policy, and patient support plans in line with business, access, and compliance requirements - Determine team structure and staffing needs, develop leaders, support succession planning, and hold teams accountable for results - Oversee external partners and ensure their work meets quality, cost, timing, and business requirements - Identify and address commercial, operational, financial, supply, legal, regulatory, medical, privacy, and promotional risks - Follow Iovance Biotherapeutics’ values, policies, procedures, ethics standards, and compliance requirements Travel - May require up to 40% travel based on business need Key Qualifications - Ability to set direction, weigh tradeoffs, and make decisions that support long-term business goals - Clear, credible communication with senior leaders and external audiences - Sound judgment in complex, uncertain, and highly regulated situations - Experience managing profit and loss, budgets, forecasts, investments, and business risks - Ability to lead change, build effective teams, develop employees, and plan for future leadership needs - Experience leading work across countries, regions, and functions, including teams outside the role’s direct reporting line - Ability to use scientific, market, customer, operating, and financial information to make clear decisions and plans - Strong negotiation, partnership, communication, and relationship-management skills Required Education, Skills, and Knowledge - Bachelor’s degree required - Fifteen or more years of increasing commercial leadership responsibility in the pharmaceutical or biotechnology industry, including experience with complex businesses, global or multi-market plans, financial results, and cross-functional teams - Experience leading a business unit, established brand, global portfolio, or similarly complex commercial operation with direct financial responsibility - Experience with hospital-administered drugs and/or oncology products - Strong knowledge of market access, reimbursement, distribution, inventory management, and customer needs for complex therapies - Experience leading office-based, field-based, cross-functional, and external partner teams, including teams that do not report directly to the role - Excellent written, verbal, presentation, and senior-level communication skills - Ability to interpret complex business and financial information and make clear recommendations to senior leaders - Commitment to integrity, inclusion, sound judgment, and compliance Preferred Education, Skills, and Knowledge - Master’s degree preferred - S. and global market experience preferred Physical Demands and Activities Required The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodation may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request accommodation. - Must be able to remain in a stationary position standing or sitting for prolonged periods of time. - Must be able to move about inside an office and exert up to 10 pounds of force occasionally or a negligible amount of force frequently or constantly to lift, carry, push, pull, or otherwise move objects. - Must have visual acuity to perform activities such as: preparing and analyzing data and figures, viewing a computer screen, and extensive reading. - This position requires repetitive motion, substantial movements (motions) of the wrist, hands, and/or fingers. - Must be able to communicate with others to exchange information. Mental Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines. Work Environment This job operates in a professional or remote office environment and requires operating standard office equipment and keyboards. #li-remote The annual base salary we reasonably expect to pay is listed. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of the role, job duties/requirements, and relevant education, experience and skills. Pay Transparency $300,000—$325,000 USD The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time. Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer, our employees and applicants will be considered without regard to an individual’s race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities, please contact careers@iovance.com. By voluntarily providing information and clicking “Submit Application”, you explicitly consent to the collection and use of your personal information for the purposes described above and in our Candidate Privacy Notice.

Executive Director, Global Commercial Proleukin

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